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We describe a 31-year-old diabetic man,with granulomatous angiitis confined to the spinal cord,who developed rapidly progressive spastic paraplegia,clinically interpreted as being secondary to a spinal cord infarct.At the time of autopsy,vasculitis was limited to the spinal cord, without involvement of cerebral vessels.The inflammatory cells were predominantly CD4+T lymphocytes,with few CD8+T and B lymphocytes.The phenotypical composition of the inflammatory infiltrate is similar to that described in other granulomatous disorders such as sarcoidosis and tuberculin reaction. |
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angiitis,granulomatous of CNS
leg weakness,bilateral
myelopathy
paraparesis,spastic
paraplegia
spinal cord
spinal cord,lesion of
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